Betsy Donovan
| Gender | Female |
| Hair Color | Dark Brown |
| Aliases | Martha Donovan |
| Religion | Roman Catholic |
| Husband: Roger Donovan | |
| Son: Clyde Donovan | |
| Daughter: Unnamed | |
| Voiced by | Former: April Stewart, "Reverse Cowgirl": Trey Parker |
| Last Appearance | Reverse Cowgirl |
Mr. and Mrs. Donovan are Clyde's parents. They are quick to join the atheist cause in "Red Hot Catholic Love" and to defend Clyde's poopscipades in "Mystery of the Urinal Deuce."