Just looking at past episodes (and their commentaries) off the top of my head, they all are against... Hate crime legislation (Chef goes nanners) Bans on smoking (Butt Out, Matt and Trey argue from the view of a business owner and against regulators) Global warming (that episode about Earth Day and...

Great episode. Gotta love the Beck parody.

I think nothing should be spoofed, unless it is extreamly obscure, like Whale Wars was. I want to have an episode like "Quest for Ratings" or "Butters Bottom Bitch" which don't have a storyline spoofing anything.